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A number of genetic disorders present with gingival manifestations which may be in the form of desquamative, ulcerative lesions or an enlargement of the gingiva. Gingival enlargement is a broad term that refers to gingival overgrowth without cause suggestion i.e. a strictly clinical description of the condition avoiding the flawed pathologic implications of terms used such as hypertrophic gingivitis or gingival hyperplasia. In this article we have summarized gingival enlargement that can be attributed to gene pathology.